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Liddle syndrome
1 OMIM reference -
2 associated genes
10 connected diseases
10 signs/symptoms
Disease Type of connection
Generalized pseudohypoaldosteronism type 1
Idiopathic bronchiectasis
Cystic fibrosis
LEOPARD syndrome
Noonan syndrome
Pilocytic astrocytoma
Syndromic multisystem autoimmune disease due to Itch deficiency
Congenital lethal myopathy, Compton-North type
Distal 22q11.2 microdeletion syndrome
Intellectual deficiency - hypotonia - spasticity - sleep disorder
Synonym(s):
- Pseudoaldosteronism
- Pseudohyperaldosteronism type 1
Classification (Orphanet):
- Rare circulatory system disease
- Rare genetic disease
- Rare renal disease
Classification (ICD10):
- Diseases of the circulatory system -
Epidemiological data:
Class of prevalence: <1 / 1 000 000
Average age onset: childhood
Average age of death: adult
Type of inheritance: autosomal dominant
External references:
1 OMIM reference -
1 MeSH reference: D056929
Gene symbol UniProt reference OMIM reference
SCNN1B P51168600760
SCNN1G P51170600761
Very frequent
- Autosomal dominant inheritance
- Cardiac rhythm disorder / arrhythmia
- Chronic arterial hypertension
- Constipation
- Hypokalemia

Frequent
- Asthenia / fatigue / weakness
- Muscle weakness / flaccidity
- Renal disease / nephropathy
- Renal failure
- Transient cerebral ischemia / stroke